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Left Main Coronary Artery Fistula Presenting as Heart Failure: A Case Report

BACKGROUND Coronary artery fistulas are rare and typically congenital but can result from various acquired conditions. They involve abnormal connections between a coronary artery and a cardiac chamber or vessel, often creating a left-to-right shunt. Most coronary artery fistulas are asymptomatic and found incidentally, though larger fistulas can cause symptoms like ischemia or heart failure, requiring intervention. Management depends on the fistula size and clinical findings. Many small fistulas...
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General

Catechol crosslinked bioprosthetic valves derived from caffeic acid and dopamine-conjugated porcine pericardia exhibit enhanced antithrombotic, immunomodulatory and anticalcification performance

The global aging population has led to an increasing prevalence of valvular heart disease (VHD), and the clinical application of bioprosthetic heart valves (BHVs) are growing with the advancement of transcatheter heart valve replacement surgery. However, BHVs, as xenogeneic pericardial tissue crosslinked with glutaraldehyde, have been affected by suboptimal cytocompatibility, thrombosis, immune response, and calcification, leading to premature degeneration and failure. Herein, a...
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