General

Managing the Giant: A Novel Approach in Orthotopic Heart Transplantation With Extreme Left Atrial Enlargement

This case report highlights an innovative surgical approach in orthotopic heart transplantation (OHT) for a patient with the largest recorded giant left atrium, measuring a biplanar volume of 1906 mL. The patient, a 63-year-old man with severe heart failure and a history of mitral and aortic valve replacements, presented with atrial fibrillation, moderate systolic dysfunction, and severe cardiomegaly. Despite optimized medical therapy, his condition warranted heart transplantation. The procedure...
Continue reading
General

Aortic and mitral valve repair in a child with rheumatic heart disease

The patient had rheumatic heart disease, which resulted in severe aortic and mitral valve regurgitation. Repair of both valves was performed at 9 years of age. During surgery, the retracted aortic valve cusps required extension with bovine pericardial patches and suture reduction annuloplasty, and the mitral valve was repaired using a Cosgrove-Edwards (Edwards Lifesciences LLC, Irvine, CA) annuloplasty band. Post-operative echocardiography showed no regurgitation in either valve. The patient is...
Continue reading
General

Transseptal access through synthetic materials: An in vitro comparative study of radiofrequency and needle-based techniques

CONCLUSION: Commercially available RF transseptal platforms successfully puncture native septa, polyester, and bovine pericardium with short-duration RF energy delivered at low forces. Metal needles remain a cost-effective option when crossing native septum, ePTFE, and bovine pericardium. However, caution should be taken when puncturing polyester with the metal needle, given that substantially higher applied forces are required. The RF wire and metal needle are reasonable options for ePTFE...
Continue reading
General

Combinatorial Glyoxal Cross-Linking and Glutamic Acid Capping for Mitigating Calcification in Bovine Pericardium

Bioprosthetic heart valves (BHVs) offer advantages over mechanical valves but are limited by long-term degeneration and calcification. This study aimed to develop a durable BHV material using decellularized bovine pericardium (BP) and alternative cross-linking strategies. BP was decellularized using a combination of sodium deoxycholate (SDC) and Triton X-100 (TX), which removed cellular components while preserving the extracellular matrix (ECM), as confirmed by histological, DNA quantification,...
Continue reading